Journal
IMMUNOLOGY
Volume 118, Issue 2, Pages 240-249Publisher
WILEY
DOI: 10.1111/j.1365-2567.2006.02362.x
Keywords
co-stimulation/costimulatory molecule; dendritic cells; regulatory T cells
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We have previously demonstrated that CD4(+) CD25(+) natural regulatory T cells (Treg cells) induce down-modulation of CD80 and CD86 (B7) molecules on dendritic cells (DCs) in vitro. In this report we show that the extent of down-modulation is functionally significant because Treg-cell conditioned DCs induced poor T-cell proliferation responses. Further, we report that down-modulation was induced rapidly and was inhibited by blocking cytotoxic T lymphocyte antigen-4 (CTLA-4), which is constitutively expressed by the Treg cells. Even though Treg cells have previously been reported to kill antigen-presenting cells, the down-modulation was not due to selective killing of DCs expressing high level of the costimulatory molecules. We propose that Treg cells down-modulate B7-molecules on DCs in a CTLA-4-dependent way, thereby enhancing suppression of T-cell activity.
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