Journal
BIOMACROMOLECULES
Volume 7, Issue 6, Pages 2059-2064Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bm060211h
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Funding
- NIGMS NIH HHS [R01 GM065917, 5 R01 GM065917-03, R01 GM065917-05] Funding Source: Medline
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The goal of this work is to make an injectable physically and chemically cross-linking NIPAAm-based copolymer system for endovascular embolization. A copolymer with N-isopropylacrylamide ( NIPAAm) and hydroxyethyl methacrylate ( HEMA) was synthesized and converted to poly(NIPAAm-co-HEMA-acrylate) functionalized with olefins. When poly(NIPAAm-co-HEMA-acrylate) was mixed with pentaerythritol tetrakis 3-mercaptopropionate (QT) stoichiometrically in a 0.1 N PBS solution of pH 7.4, it formed a temperature-sensitive hydrogel with low swelling through the Michael-type addition reaction and showed improved elastic properties at low frequency compared to physical gelation. This material could be useful for applications requiring water-soluble injection but lower swelling and lower creep properties than available with other soluble in-situ-gelling materials.
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