Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 21, Issue 6, Pages 876-885Publisher
WILEY
DOI: 10.1359/JBMR.060310
Keywords
macrophage migration inhibitory factor; transgenic mice; osteoporosis; matrix metalloproteinase
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The bone phenotype of mice overexpressing MIF was studies. These mice showed decreased trabecular bone, increased bone formation rate, and increased MMP-3, -9, and -13 mRNA expression in the femora and tibias. This model provides evidence of the role played by MIF in bone remodeling and balance in vivo.
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