Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 49, Issue 11, Pages 3045-3048Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm050948+
Keywords
-
Categories
Funding
- NIAID NIH HHS [UC1 AI049514] Funding Source: Medline
- PHS HHS [UC1A149514] Funding Source: Medline
Ask authors/readers for more resources
A diverse 5000-compound library was synthesized from commercially available diamines and screened for activity against Mycobacterium tuberculosis in vitro, revealing 143 hits with minimum inhibitory concentration (MIC) equal to or less than 12.5 mu M. New prospective scaffolds with antitubercular activity derived from homopiperazine, phenyl- and benzyl-substituted piperazines, 4-aminomethylpiperidine, 4-aminophenylethylamine, and 4,4'-methylenebiscyclohexylamine were identified. Compound SQ775 derived from homopiperazine and compound SQ786 derived from benzylpiperazine had potent antimicrobial activity against M. tuberculosis in experimental animals in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available