Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 163, Issue 6, Pages 1103-1105Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.163.6.1103
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Objective: The purpose of this study was to examine the potential association of the serotonin transporter (5-HTT) gene and childhood aggression by testing the 5-HTT variable-number-tandem-repeat and serotonin transporter promoter polymorphism 5-HTTLPR), including the recently discovered Lg allelic variant of 5-HTTLPR. Method: Clinically referred children displaying extreme aggression, with a minimum 2-year history, were genotyped for 5-HTTLPR (N=77) and 5-HTT variable-number-tandem-repeat (N=78). Analyses compared genotype frequencies of the agressive children with healthy comparison subjects. Results: The low expressing genotypic variants of the 5-HTTLPR polymorphism (S/S, Lg/S, Lg/Lg) were significantly associated with childhood aggression. Conclusions: This is the first study to report a significant association between the 5-HTTLPR gene and childhood
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