Journal
ANNALS OF ONCOLOGY
Volume 24, Issue 1, Pages 165-171Publisher
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mds206
Keywords
carcinoma of esophagus; chemoradiation; chemoradiotherapy; esophagectomy; squamous cell esophageal carcinoma
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Funding
- Research Grant Council of Hong Kong Special Administrative Region, China
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The aim of this study was to report on the 5-year survival outcomes of patients with resectable esophageal carcinoma who were treated by definitive chemoradiotherapy (CRT) or standard esophagectomy. Between July 2000 and December 2004, 81 patients with resectable squamous cell carcinoma of the mid- or lower thoracic esophagus were randomized to receive esophagectomy or definitive CRT. The primary outcome was the overall survival and secondary outcomes included disease-free survival, morbidities and mortalities. Forty-five patients received esophagectomy and 36 patients were treated by definitive CRT. The overall 5-year survival favors CRT but the difference did not reach statistical significance (surgery 29.4% and CRT 50%, P = 0.147). A trend to improved 5-year survival was observed for patients suffering from node-positive disease (P = 0.061). The 5-year disease-free survival also showed a trend to significance favoring CRT (P = 0.068), particularly for patients suffering from node-positive disease (P = 0.017). Both the stage of the disease and albumin level were significant predictors to mortality and disease-free survival. Definitive CRT for squamous esophageal carcinoma resulted in comparable long-term survival to surgery. Further large-scale studies would be required to further investigate the role of CRT in node-positive patients. Clinicaltrials.gov identifier: NCT01032967.
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