Journal
ADDICTIVE BEHAVIORS
Volume 31, Issue 6, Pages 1010-1034Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.addbeh.2006.03.047
Keywords
substance use abuse dependence; factor analysis; latent class analysis; factor mixture models; item response theory; twins; relatives; contingent response data; skip pattern; missing data; misuse
Categories
Funding
- NCRR NIH HHS [RR-08123] Funding Source: Medline
- NIDA NIH HHS [DA-18673] Funding Source: Medline
- NIMH NIH HHS [MH-01458, MH-65322] Funding Source: Medline
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The measurement of behavior is inherently problematic, and this is especially true of substance use and abuse phenotypes. The contingent nature of many assessments, such that symptoms of abuse and dependence cannot be obtained from those who have not initiated substance use, presents special difficulties. Furthermore, it is not clear whether individual differences in liability to use, abuse and dependence are best characterized as dimensions or classes or a combination of both. This article outlines research designs and methods suitable for quantifying liability to substance use. The value of data collected from relatives is emphasized in this context, as they permit identification of models normally compromised because data on, e.g., substance dependence symptoms, are systematically missing in those who have not initiated use of the substance in question. (c) 2006 Published by Elsevier Ltd.
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