Journal
JOURNAL OF IMMUNOLOGY
Volume 176, Issue 11, Pages 6973-6981Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.176.11.6973
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Funding
- MRC [MC_U190081962, MC_U137884180, MC_U190081958] Funding Source: UKRI
- Medical Research Council [MC_U190081958, MC_U137884180, MC_U190081962] Funding Source: researchfish
- Medical Research Council [MC_U137884180, MC_U190081958, MC_U190081962] Funding Source: Medline
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Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4(+) T cell count and a strong HIV-specific CD4(+) T cell response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a crosssectional study of HIV Gag-specific T cell function in HIV-1- and HIV-2-infected Gambians. Using cytokine flow cytometry and lymphoproliferation assays, we show that HIV-specific CD4(+) T cells from HIV-2-infected individuals maintained proliferative capacity, were not terminally differentiated (CD57(-)), and more frequently produced IFN-gamma or IL-2 than CD4(+) T cells from HIV-1-infected donors. Polyfunctional (1FN-gamma(+)/1L-2(+)) HIV-specific CD4(+) T cells were found exclusively in HIV-2(+) donors. The disparity in CD4(+) T cell responses between asymptomatic HIV-1- and HIV-2-infected subjects was not associated with differences in the proliferative capacity of HIV-specific CD8(+) T cells. This study demonstrates that HIV-2-infected donors have a well-preserved and functionally heterogeneous HIV-specific memory CD4(+) T cell response that is associated with delayed disease progression in the majority of infected people.
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