Journal
PHYTOMEDICINE
Volume 13, Issue 6, Pages 442-445Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2005.01.014
Keywords
Rheedia gardneriana; benzophenone; endothelium; nitric oxide; lipoxygenase; cyclooxygenase
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The vascular effects of 7-epiclusianone on the rat aorta were investigated. In the rat aortic rings with functional endothelia, 7-epiclusianone up to 10 mu M induced a concentration-dependent vasodilatation of the sustained contractions induced by phenylephrine (0.3 mu M). At concentrations higher than 10 mu M, 7-epiclusianone induced a concentration-dependent contraction in the aortic rings. The vasodilator effect of 7-epiclusianone was drastically decreased with L-NAME (100 mu M) as well as in endothelium-denuded aortic rings. Moreover, indomethacin (10 mu M) induced a significant shift to the left in the vasodilator but did not modify the vasoconstrictor effect of 7-epiclusianone. In arteries without pre-contraction, 7-epiclusianone (3-100 mu M) induced concentration-dependent contraction only in endothelium-intact and in the presence of L-NAME (100 mu M). This effect was inhibited by indomethacin (10 mu M) and ZM230487 (1 mu M), selective inhibitors of cyclooxygenase and of 5-lipoxygenase, respectively. We can conclude that at low concentrations 7-epiclusianone induces an endothelium-dependent vasodilator effect in rat aortic rings. At higher concentrations and in conditions where NO synthase was inhibited, 7-epiclusianone induces a vasocontractile effect. Nitric oxide seems to participate in the vasodilatation, while endothelial cyclooxygenase- and 5-lipoxygenase-derived products play a role in the vasoconstrictor effect. (c) 2005 Elsevier GmbH. All rights reserved.
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