Journal
PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 25, Issue 6, Pages 562-564Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.inf.0000219401.70804.1a
Keywords
linezolid resistance; Staphylococcus aureus; hyper-IgE syndrome
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Funding
- Intramural NIH HHS Funding Source: Medline
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We report 2 sisters with hyper-IgE syndrome treated with daily suppressive dosages of linezolid (LZD) who developed LZD-resistant Staphylococcus aureus carrying the G2576T mutation in the 23S rRNA gene. Molecular typing suggested transmission of the resistant strain from one sister to the other. LZD-susceptible S. aureus was isolated 2 months after LZD discontinuation. LZD-resistant S. aureus remains rare but may occur while receiving suppressive therapy.
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