Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 55, Issue 2, Pages 89-94Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2005.10.013
Keywords
Streptococcus pneumoniae; urinary antigen assay; children
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The aim of the study was to evaluate the Binax Now rapid immunochromatographic test (ICT) for the detection of Streptococcus pneumoniae urinary antigen in children suffering from potentially pneumococcal infections. A total of 287 patients, with a median age of 34.9 months and divided into 3 groups, were Studied; the first group of patients with a suspected pneumococcal infection (n = 112), the second group with infections symptoms nonsuggestive of a pneumococcal infection (n = 54), and the third group was composed of asymptomatic children (n = 121). In group 1, sensitivity of ICT was 100% and specificity was 55.9% (95% confidence interval, 44.1- 67.7). Forty-six (85.1%) patients from the second group were true negatives. Twenty-five (20.7%) patients front the third study group were nasopharyngeal pneumococcal carriers, and the ICT was positive in 13 carriers (10.7%). The high sensitivity level of ICT in our study indicates that a negative test Could rule out a pneumococcal infection, contrasted with a poor specificity. (c) 2006 Elsevier Inc. All rights reserved.
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