Journal
PROTEOMICS
Volume 6, Issue 11, Pages 3455-3465Publisher
WILEY
DOI: 10.1002/pmic.200500770
Keywords
hepatocytes; liver transplantation; oxidative stress
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Knowledge of early molecular events occurring upon ischemia/reperfusion (I/R) during liver transplantation (IT) is of great importance to improve the therapeutic intervention of surgical treatment. However, nowadays, few data are available on early protein targets of I/R injury. To 14 identify these proteins, we used a differential proteomics approach in the characterization human liver biopsies during I/R upon LT. Analyses were performed on nine donor livers during LT. By using 2-DE and MALDI-TOF MS, we identified 36 proteins which resulted significantly altered upon I/R injury. The majority of these proteins are functionally involved in lipid and energy metabolism, in different metabolic pathways, in redox signalling and in oxidative-stress response. Our data represent the first global approach in the study of I/R injury in liver.
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