Journal
ANNALS OF ONCOLOGY
Volume 22, Issue 7, Pages 1554-1560Publisher
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdq617
Keywords
AJCC TNM staging; breast cancer subtype; triple-negative breast cancer (TNBC)
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Funding
- Ministry of Health and Welfare, Republic of Korea [0412-CR01-0704-0001]
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Patients and methods: We conducted a retrospective analysis of invasive breast cancer patients who received curative surgery at Samsung Medical Center from 2000 to 2004. Relapse-free survivals (RFS) by stage were analyzed. Results: Thousand eight hundred and seventy-nine patients who were available clinicopathologic data were included. These patients were divided into three subtypes: hormone receptor (HR)+, human epidermal growth factor receptor 2+, and triple negative groups. As the stage became more advanced, the slope of each stage of the RFS curves of patients with HR+ and HER2+ steadily increased. In contrast, RFS curves intermingled and showed overlap from stage 1 to 3A in TNBC patients. There was only wide separation of RFS curves between stage 1-3A and 3B-3C in TNBC. Conclusions: The current TNM staging system might not be enough for encompassing the tumor biology and for predicting outcomes to make therapeutic decisions for all BCs, especially for TNBC patients.
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