Journal
NEOPLASIA
Volume 8, Issue 6, Pages 465-469Publisher
ELSEVIER SCIENCE INC
DOI: 10.1593/neo.06283
Keywords
TMPRSS2/ERG rearrangements; microhomology; genome architecture; FISH; genomic microdeletions
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The recent description of novel recurrent gene fusions in similar to 80% of prostate cancer (PCa) cases has generated increased interest in the search for new translocations in other epithelial cancers and emphasizes the importance of understanding the origins and biologic implications of these genomic rearrangements. Analysis of 15 PCa cases by reverse transcription-polymerase chain reaction was used to detect six ERG-related gene fusion transcripts with TMPRSS2. No TMPRSS2/ETV1 chimeric fusion was detected in this series. Three-color fluorescence in situ hybridization confirms that TMPRSS2/ERG fusion may be accompanied by a small hemizygous sequence deletion on chromosome 21 between ERG and TMPRSS2 genes. Analysis of genomic architecture in the region of genomic rearrangement suggests that tracts of microhomology could facilitate TMPRSS2/ERG fusion events.
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