Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 54, Issue 6, Pages 775-778Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.54.775
Keywords
Ulmaceae; Ulmus pumila; root bark; triterpenoid; cytotoxicity
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Three new triterpenoids, 1-3, were isolated from the dried root bark of Ulmus pumila. Along with the three new compounds, six known triterpenoids, epifriedelanol (4), friedelin (5), oleanolic acid (6), maslinic acid (7), camaldulenic acid (8), and arjunolic acid (9) were also isolated. The structures of new compounds were established as ulmudiol (bauer-7-ene-1 alpha,3 beta-diol, 1), dehydroulmudiol [bauer-7,9(11)-diene-1 alpha 3 beta-diol, 2], and ulmuestone [3 alpha-hydroxy-11 alpha-(4'-hydroxy-3'-methoxy)benzoyloxybauer-1-one, 3], on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. In addition, the cytotoxic activities of these compounds are also reported.
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