Journal
ANNALS OF ONCOLOGY
Volume 22, Issue 9, Pages 2049-2056Publisher
ELSEVIER
DOI: 10.1093/annonc/mdq716
Keywords
China; gastric cancer; lymph node ratio; prognosis; UICC TNM system 7th edition
Categories
Funding
- Science and Technology Projects of Guangdong Province [2008B030301103, 2010B031600071]
Ask authors/readers for more resources
Background: In this study, we assessed the prognostic value of the lymph node ratio (LNR), established a hypothetical tumor-ratio-metastasis (TRM) staging system and compared it with the 7th edition International Union Against Cancer pathological N (pN) and tumor-node-metastasis (TNM) system. Patients and methods: A total of 1343 gastric cancer patients undergoing D2 resection were staged using the TRM staging system and the 7th edition TNM system. Optimal cut points of LNR were calculated using X-tile software and validated by bootstrapping. Homogeneity, discriminatory ability, and monotonicity of gradients of the TRM and TNM systems were compared using linear trend chi(2), likelihood ratio chi(2) statistics, and Akaike information criterion (AIC) calculations. Results: Optimal cut points classified patients into LNR0 (0%), LNR1 (1%-30%), LNR2 (31%-60%), and LNR3 (61%-100%) groups. In univariate, multivariate and stratified analyses, the LNR staging showed superiority to the 7th edition pN staging. The TRM staging system had higher linear trend and likelihood ratio chi(2) scores and smaller AIC values compared with those for the TNM system, which represented the optimum prognostic stratification. Conclusions: The novel TRM staging system predicts survival of gastric cancer more accurately than the 7th edition TNM system. It may be considered as an alternative to TNM system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available