Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 117, Issue 6, Pages 1415-1418Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2006.04.003
Keywords
urticaria; anaphylaxis; most cells; IgE
Categories
Funding
- NHLBI NIH HHS [HL-36110] Funding Source: Medline
- NIAID NIH HHS [AI-52353, AI-48802, AI-31599] Funding Source: Medline
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A case of a girl who presented at age 12 years with idiopathic cold urticaria is described. Her reactions to the cold became progressively more severe over a period of approximately 2 years, despite therapy with H1 antagonists and a type I receptor for cysteinyl leukotrienes receptor antagonist. She began to experience systemic symptoms on immersion in ocean water. She was atopic and had moderate persistent asthma. A trial of anti-IgE resulted in complete resolution of her urticaria and its associated manifestations. These findings should prompt a reexamination of the potential pathogenetic role played by IgE and its high-affinity receptor on mast cells in idiopathic cold urticaria.
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