4.5 Article

Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 11, Pages 2842-2845

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.03.020

Keywords

IRAK-4; kinase; inflammation; kinase inhibitor

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High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4. (c) 2006 Elsevier Ltd. All rights reserved.

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