Journal
ANALYTICAL CHEMISTRY
Volume 78, Issue 11, Pages 3638-3642Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ac052289e
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The rupture forces between an aptamer ( 1)-functionalized AFM tip and a thrombin-modified Au surface are analyzed. The rupture force for a single aptamer/thrombin complex is determined as similar to 4.45 pN. The analysis of the system reveals that the rupture forces correspond to the melting of the G-quadruplex structure of the aptamer bound to the thrombin. This melting of the G-quadruplex leads to the dissociation of the aptamer/thrombin complex.
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