A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls:: A double-blinded randomized placebo-controlled 1-year intervention

The effect of vitamin D supplementation on bone mineral augmentation in 212 adolescent girls with adequate calcium intake was studied in a randomized placebo-controlled setting. Bone mineral augmentation determined by DXA increased with supplementation both in the femur and the lumbar vertebrae in a dose-responsive manner. Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers.