Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 12, Pages 6177-6181Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02625-05
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Funding
- NHLBI NIH HHS [HL59725, R01 HL059725] Funding Source: Medline
- NIAID NIH HHS [P30 AI027742, AI27742, AI36085, R01 AI036085] Funding Source: Medline
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Only five monoclonal antibodies (MAbs) neutralizing a broad range of primary isolates (PI) have been identified up to now. We have found that some MAbs with no neutralizing activities according to the conventional neutralization assay, involving phytohemagglutinin-stimulated peripheral blood mononuclear cells as targets, efficiently inhibit the replication of human immunodeficiency virus type 1 (HIV-1) PI in macrophages and immature dendritic cells (iDC). The mechanism of inhibition is distinct from the neutralization of infectivity occurring via Fab fragments and involves the interaction of the F portion with the Fc gamma Rs present on macrophages and iDC. We propose that, if such nonneutralizing inhibitory antibodies limit mucosal HIV transmission, they should be induced by vaccination.
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