Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 13, Issue 6, Pages 509-516Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1092
Keywords
-
Funding
- NCI NIH HHS [P30CA100730, P01CA16058] Funding Source: Medline
- NIGMS NIH HHS [R01 GM038277] Funding Source: Medline
Ask authors/readers for more resources
RNA helicase A (RHA) is a highly conserved DEAD-box protein that activates transcription, modulates RNA splicing and binds the nuclear pore complex. The life cycle of typical mRNA involves RNA processing and translation after ribosome scanning of a relatively unstructured 5' untranslated region (UTR). The precursor RNAs of retroviruses and selected cellular genes harbor a complex 5' UTR and use a yet-to-be-identified host post-transcriptional effector to stimulate efficient translation. Here we show that RHA recognizes a structured 5-terminal post-transcriptional control element (PCE) of a retrovirus and the JUND growth-control gene. RHA interacts with PCE RNA in the nucleus and cytoplasm, facilitates polyribosome association and is necessary for its efficient translation. Our results reveal a previously unidentified role for RHA in translation and implicate RHA as an integrative effector in the continuum of gene expression from transcription to translation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available