Journal
PLANTA MEDICA
Volume 72, Issue 7, Pages 590-595Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2006-931565
Keywords
Saussurea conica; Asteraceae; conicaols A and B; conicaoside; NO production suppressing activity
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Three new lignan derivatives, conicaols A and B and conicaoside, together with seven known compounds were identified from Saussurea conica. Their structures were elucidated by spectral methods including 1D and 2D NMR techniques. Six 2,3-dibenzylbutyrolactone-type lignans were biologically evaluated, and two of them, arctigenin and matairesinol, showed potent activity to suppress NO production in vitro in LPS-activated macrophages of SD rat.
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