Journal
BIOLOGICALS
Volume 34, Issue 2, Pages 151-154Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biologicals.2006.02.010
Keywords
IPV; Sabin strains; D-antigen; immunogenicity
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In the course of Sabin-inactivated poliovirus vaccine (S-IPV) development, we have established high-yield virus production techniques based on Vero cell micro-carrier cultures. Development of specific ELISA tests to quantify the antigen content of S-IPV has been achieved. To adjust the immunogenicity of S-IPV so as to be comparable with the conventional-IPV, a new formulation was determined using a potency test using rats. The reformulated S-IPV was shown to be efficacious for the immunization of monkeys. (c) 2006 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.
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