Journal
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
Volume 40, Issue 3-4, Pages 111-120Publisher
ELSEVIER
DOI: 10.1016/j.molcatb.2006.02.010
Keywords
biocatalysis; lipases; enzymatic resolution; desymmetrization; pharmaceuticals
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Biocatalysis offers a clean and ecological way to perform chemical processes, in mild reaction conditions and with high degree of selectivity. The use of enzymes, specially lipases, in organic solvents proves an excellent methodology for the preparation of single-isomer chiral drugs. This review covers some general aspects and representative examples of the use of lipases for the enantioselective or regioselective preparation of alcohol and amine intermediates in the synthesis of pharmaceuticals. (c) 2006 Elsevier B.V. All rights reserved.
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