Journal
ANNALS OF ONCOLOGY
Volume 20, Issue 7, Pages 1270-1274Publisher
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdn768
Keywords
BEACOPP; chemotherapy; Hodgkin's lymphoma; PET; response assessment
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Funding
- MZ CR IGA NR [8033-6/2004]
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Patients and methods: From January 2004 to March 2007, 50 patients with newly diagnosed HL in clinical stages IIB with large mediastinal mass or extranodal disease, III and IV were treated according to the HD15 protocol of the German Hodgkin Study Group. All patients received a PET scan after four cycles of BEACOPP (PET-4). Results: Of the overall group, 14 of 50 patients had a positive PET-4 while 36 had a negative PET-4. At a median observation time of 25 months, 2 of the 14 patients with a positive PET-4 had progressed or relapsed, while there was no progression or relapse in PET-4-negative patients. Conclusion: Our results indicate a very good negative predictive value of PET-4 in advanced-stage HL patients treated with BEACOPP.
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