Journal
TETRAHEDRON LETTERS
Volume 47, Issue 23, Pages 3853-3856Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.03.181
Keywords
polyethylene glycol (PEG-400); beta-ketosulfones; alpha-haloketone; sodium alkyl/aryl sulphinate
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An efficient and convenient synthesis of beta-ketosulfones is described. Reaction of an alpha-haloketone with sodium alkyl/aryl sulphinate yields the corresponding beta-ketosulfone promoted by polyethylene glycol (PEG-400) as an efficient reaction medium. (c) 2006 Elsevier Ltd. All rights reserved.
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