Journal
VACCINE
Volume 24, Issue 23, Pages 5027-5035Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2006.03.064
Keywords
FI-RSV; MPL; cotton rat
Categories
Funding
- NIAID NIH HHS [AI-44936, R01 AI057575, AI-057575] Funding Source: Medline
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Formalin-inactivated respiratory syncytial virus vaccine (FI-RSV) induces a poorly understood immunopathological response that leads to disease enhancement upon RSV infection of vaccinees. In the cotton rat model, inclusion of monophosphoryl lipid A (MPL) in the FI-RSV formulation was found to mitigate the lung pathology associated with vaccine-enhanced disease. Here we report that the protective effect of MPL on FI-RSV vaccine-enhanced disease is associated with a dramatic reduction in levels of Th1- and Th2-type cytokines and chemokines normally elicited in response to RSV challenge. Our data illustrate the complexity of proinflammatory response elicited by FI-RSV vaccination and RSV infection and the potential importance of MPL in modifying this response. (c) 2006 Elsevier Ltd. All rights reserved.
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