Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 315, Issue 1-2, Pages 110-121Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2006.02.019
Keywords
self-emulsified drug delivery system; coenzyme Q(10); optimization; controlled release; face-centered cubic design; stability
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The objective of this study was to evaluate the effect of some processing parameters on the release of lipid formulation from a tablet dosage form. A 17-run, face-centered cubic design was employed to evaluate the effect of colloidal silicates (XI), magnesium stearate mixing time (X-2), and compression force (X-3) on flow, hardness, and dissolution of Coenzyme Q(10) (CoQ(10)) lipid formulation from a tablet dosage form. The optimized formulation was subsequently subjected to a short-term accelerated stability study. All preparations had a flowability index values ranging from 77 to 90. The cumulative percent of CoQ10 released within 8 It (Y-5) ranged from 40.6% to 90% and was expressed by the following polynomial equation: Y-5 = 49.78 - 16.36X(1) + 2-90X(2) - 3.11X(3) - 0.37X(1)X(2) + 1.06X(1)X(3) - 1.02X(2)X(3) + 11.98X(2)(1) + 10.63 X-2(2) - 7.10X(3)(2). When stored at 4 degrees C, dissolution rates were retained for up to 3 months. Storage at higher temperatures, however, accelerated lipid release and caused leakage, and loss of hardness. Processing parameters have a profound effect on the release of lipid formulations from their solid carriers. While optimized controlled release formulations could be attained, further considerations should be made to prepare liquisolids that are physically stable at higher storage temperatures. (c) 2006 Elsevier B.V. All rights reserved.
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