Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 41, Issue 3, Pages 1017-1021Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2006.01.021
Keywords
amphiphilie beta-cyclodextrin; nanosphere suspension; metronidazole
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Several aspects of the manufacture of nanospheres containing metronidazole were studied. Nanospheres made of amphiphilic beta-cyclodextrin containing metronidazole were prepared by adding an acetone solution of amphiphilic cyclodextrin to an aqueous solution of metronidazole with or without Pluronic PE/F68 (R) as the surfactant. An optimized formulation with high encapsulation efficiencies and with an appropriate particle size for intravenous administration, was developed. The entrapment of metromidazole was strongly dependent of the method of preparation and drug concentrations. These nanospheres prepared by nanocrystallization are promising carriers for metromidazole in the treatment of hepatic abscess. (c) 2006 Elsevier B.V. All rights reserved.
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