Journal
SCIENCE
Volume 312, Issue 5779, Pages 1520-1523Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1123841
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Funding
- NIGMS NIH HHS [R01 GM072764, GM072764, GM45697] Funding Source: Medline
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The embryos of seed plants develop with an apical shoot pole and a basal root pole. In Arabidopsis, the topless-1 (tpl-1) mutation transforms the shoot pole into a second root pole. Here, we show that TPL resembles known transcriptional corepressors and that tpl-1 acts as a dominant negative mutation for multiple TPL-related proteins. Mutations in the putative coactivator HISTONE ACETYLTRANSFERASE GNAT SUPERFAMILY1 suppress the tpl-1 phenotype. Mutations in HISTONE DEACETYLASE19, a putative corepressor, increase the penetrance of tpl-1 and display similar apical defects. These data point to a transcriptional repression mechanism that prevents root formation in the shoot pole during Arabidopsis embryogenesis.
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