Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 12, Pages 4700-4702Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo060572n
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A versatile approach has been developed for the multiple labeling of oligonucleotides. First, three linkers as a H-phosphonate monoester derivative were condensed on a solid-supported T-12 to introduce H-phosphonate diester linkages which were oxidized in the presence of propargylamine. Second, three galactosyl azide derivatives were conjugated to the solid-supported three-alkyne-modified T-12 by a 1,3-cycloaddition so-called click chemistry in the presence of Cu( I) assisted by microwaves.
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