Journal
NEUROSCIENCE LETTERS
Volume 400, Issue 3, Pages 258-261Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.02.058
Keywords
allodynia; neuropathy; microglia; astrocytes; propentofyl line; vincristine
Categories
Funding
- NIAMS NIH HHS [AR44757] Funding Source: Medline
- NIDA NIH HHS [DA11276, DA05969] Funding Source: Medline
Ask authors/readers for more resources
The development of painful peripheral neuropathy is a dose-limiting side effect of numerous cancer chemotherapeutic agents. The present study utilized a rodent model of vincristine-induced neuropathy to determine whether a glial modulating agent, propentofylline, could attenuate vincristine-induced mechanical allodynia. Intravenous vincristine administered on days 1 through 5 and days 8 through 11 produced mechanical allodynia using 2 and 12g von Frey filaments. Lumbar spinal cord from animals on day 15 expressed mild bilateral microglial and astrocytic activation as compared to saline-treated animals. Daily intraperitoneal propentofylline at 10 mg/kg attenuated mechanical allodynia induced by vincristine administration. In addition, propentofylline was found to decrease spinal microglial and astrocytic activation on day 15. These data suggest that central glial cells may play an important role in the development of painful neuropathy following vincristine administration. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available