Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 203, Issue 6, Pages 1419-1425Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20052554
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Funding
- Medical Research Council [G0400701] Funding Source: researchfish
- MRC [G0400701] Funding Source: UKRI
- Medical Research Council [G0400701] Funding Source: Medline
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Collagens are the most abundant proteins in the human body, important in maintenance of tissue structure and hemostasis. Here we report that collagens are high affinity ligands for the broadly expressed inhibitory leukocyte-associated immunoglobulin-like receptor-1 ( LAIR-1). The interaction is dependent on the conserved Gly-Pro-Hyp collagen repeats. Antibody crosslinking of LAIR-1 is known to inhibit immune cell function in vitro. We now show that collagens are functional ligands for LAIR-1 and directly inhibit immune cell activation in vitro. Thus far, all documented ligands for immune inhibitory receptors are membrane molecules, implying a regulatory role in cell-cell interaction. Our data reveal a novel mechanism of peripheral immune regulation by inhibitory immune receptors binding to extracellular matrix collagens.
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