Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 49, Issue 12, Pages 3748-3752Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm060295c
Keywords
-
Categories
Ask authors/readers for more resources
A new antitrypanosomal hit compound that cures an acute ( STIB 900) mouse model of Trypanosoma brucei rhodesiense trypanosomiasis is described. This bis( 2-aminoimidazolinium) dicationic compound proved to be an excellent DNA minor groove binder, suggesting a possible mechanism for its trypanocidal activity. From these studies, the 4,4'-diaminodiphenylamine skeleton emerged as a good scaffold for antitrypanosomal drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available