Journal
BIOINFORMATICS
Volume 22, Issue 12, Pages 1532-1533Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btl143
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Funding
- MRC [MC_U105161047] Funding Source: UKRI
- Medical Research Council [MC_U105161047] Funding Source: researchfish
- Medical Research Council [MC_U105161047] Funding Source: Medline
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We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.
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