Journal
ANNALS OF NUTRITION AND METABOLISM
Volume 64, Issue 2, Pages 127-136Publisher
KARGER
DOI: 10.1159/000363392
Keywords
Obesity; Leptin; -2548 G/A polymorphism; Meta-analysis
Categories
Funding
- National Natural Science Foundation of China [81001260]
- Zhejiang Provincial Natural Science Foundation (China) [Y2100794]
- 'New Century 151 Talent Program' of Zhejiang Province (China)
- Science and Technology Plan of Zhejiang Province (China) [2011F20038, 2013F10007, 2009R50028]
- Zhejiang Medical and Health Science and Technology Plan Project (China) [2011ZDA001, 2014ZDA004]
- Medical Supporting Disciplines of Nutrition in the Zhejiang Province [11-zc03]
- Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents (China)
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Background: A common single-nucleotide polymorphism identified in the 5'-untranslated region of the leptin gene (LEP -2548 G/A polymorphism) may be associated with obesity, but the existing research findings are inconsistent, so we conducted this meta-analysis. Methods: Medline, Embase and ISI Web of Science databases were searched to identify relevant studies. Meta-analysis of the total and subgroup populations was conducted using allelic, additive, dominant and recessive models, and odds ratios and their 95% confidence intervals were calculated in a fixed-effect model if no heterogeneity (evaluated as 12 statistic) existed. Otherwise, a random-effects model was adopted. Subgroup analysis was performed by ethnicity. Meta-regression and the HETRED analysis were used to explore the potential sources of between-study heterogeneity. Egger's test and influence analysis were conducted to evaluate the publication bias and study power, respectively. Results: The final selection enrolled 9 studies, including 2,988 subjects (1,372 obese subjects and 1,616 controls). No significant association was identified between the LEP -2548 G/A polymorphism and obesity for all genetic models in the overall population and Caucasians. We found a significant association with allelic, additive and dominant models for subjects of mixed race from South America. Notwithstanding, this significance should be treated cautiously for it is based on a rather small sample (788 involved subjects). Conclusions: In total, the combined analysis of data from current and published studies suggested that the LEP -2548 G/A polymorphism does not contribute to the development of obesity, despite the fact that a significant association exists in a small subgroup from South America. Further studies are needed to elucidate the relationship. (C) 2014 S. Karger AG, Basel
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