Journal
SCIENCE
Volume 312, Issue 5780, Pages 1665-1669Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1125893
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI54902] Funding Source: Medline
- NIAMS NIH HHS [NIH RO1 AR44894] Funding Source: Medline
Ask authors/readers for more resources
The susceptibility locus for the autoimmune disease lupus on murine chromosome 1, Sle1(z)/Sle1b(z), and the orthologous human locus are associated with production of autoantibody to chromatin. We report that the presence of Sle1(z)/Sle1b(z) impairs B cell anergy, receptor revision, and deletion. Members of the SLAM costimulatory molecule family constitute prime candidates for Sle1b(z), among which the Ly108.1 isoform of the Ly108 gene was most highly expressed in immature B cells from lupus-prone B6. Sle1(z) mice. The normal Ly108.2 allele, but not the lupus-associated Ly108.1 allele, was found to sensitize immature B cells to deletion and RAG reexpression. As a potential regulator of tolerance checkpoints, Ly108 may censor self-reactive B cells, hence safeguarding against autoimmunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available