Synthesis of novel halo-oxybispyridines, new building blocks in cholinergic medicinal chemistry

This paper describes a method for the preparation of oxybispyridines bearing several halogens, which could be further transformed into other functional groups thus giving access to libraries with the bis-pyridyl ether moiety as the common structural feature of interest in cholinergic medicinal chemistry. Scope and limitation of the method are outlined. (c) 2006 Elsevier Ltd. All rights reserved.