Journal
WORLD JOURNAL OF GASTROENTEROLOGY
Volume 12, Issue 23, Pages 3651-3656Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v12.i23.3651
Keywords
DLG5; association; gender; genetic heterogeneity; inflammatory bowel disease; Crohn disease
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In 2004, an association of genetic variation in the discs large homolog 5 (DLG5) gene with inflammatory bowel disease (IBD) was described in two large European study samples([1]). The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectively, leading to controversial findings and ongoing discussions concerning the validity of the initial association finding and its role in the aetiology of Crohn disease. This review aims to summarize the current state of knowledge and to place the reported findings in the context of current concepts of complex diseases. This includes aspects of statistical power, phenotype differences and genetic heterogeneity between different populations as well as gene-gene and gene-environment interactions. (c) 2006 The WJG Press. All rights reserved.
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