Journal
TETRAHEDRON LETTERS
Volume 47, Issue 26, Pages 4415-4418Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.04.082
Keywords
microwave; palladium; cross-coupling; heterocycles; regioselectivity
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We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross-coupling reactions of 2,4-di- and 2,4,5-trihalopyrimidines with phenoylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the heterocycle. In addition, we show that this methodology, is ameneable for the stepwise preparation of mono-, di-, and triphenylpyrinlidines. (c) 2006 Elsevier Ltd. All rights reserved.
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