Journal
POLYMER
Volume 47, Issue 14, Pages 5124-5130Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2006.04.063
Keywords
micromolding; microwells; PDMS scaffold
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We introduce an innovative fabrication of the polymer scaffolds for tissue culture by utilizing the evaporation induced self-assembled micropatterns of poly styrene-block-poly(acrylic acid) (PS-b-PAA) diblock copolymer micelles. The microstructures were used as templates for micromolding a silicon elastomer, poly(dimethylsiloxane) (PDMS), into tissue scaffolds and microwells for cell patterning purpose. Cultivation of human epithelial cells (Calu-3 cell line) on the PDMS scaffolds demonstrates potential applications in tissue engineering and cell-based biosensors. The reported method is rapid, simple, economical, and versatile comparing with the existing microfabrication techniques. (c) 2006 Elsevier Ltd. All rights reserved.
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