Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 49, Issue 13, Pages 3763-3765Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm060458x
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An antiapoptotic polymeric nanomedicine, PGA-peptoid 1, has been developed by the conjugation of a novel apoptotic protease activating factor 1 (Apaf-1) inhibitor (peptoid 1) to poly-L-glutamic acid (PGA). Full structural and biophysical characterization of the conjugate by different techniques has been accomplished. This macromolecule clearly enhances the antiapoptotic activity of peptoid 1 in different cell models.
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