Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 147, Issue 1, Pages 69-78Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2006.01.008
Keywords
reproducibility; statistical analysis; fractional anisotropy; mean diffusivity; magnetic resonance imaging
Categories
Funding
- Intramural NIH HHS Funding Source: Medline
- NIMH NIH HHS [Z01 MH002716-11] Funding Source: Medline
Ask authors/readers for more resources
The characterization of measurement error is critical in assessing the significance of diffusion tensor imaging (DTI) findings in longitudinal and cohort studies of psychiatric disorders. We studied 20 healthy volunteers, each one scanned twice (average interval between scans of 51 +/- 46.8 days) with a single shot echo planar DTI technique. Intersession variability for fractional anisotropy (FA) and Trace (D) was represented as absolute variation (standard deviation within subjects: SDw), percent coefficient of variation (CV) and intraclass correlation coefficient (ICC). The values from the two sessions were compared for statistical significance with repeated measures analysis of variance or a non-parametric equivalent of a paired t-test. The results showed good reproducibility for both FA and Trace (CVs below 10% and ICCs at or above 0.70 in most regions of interest) and evidence of systematic global changes in Trace between scans. The regional distribution of reproducibility described here has implications for the interpretation of regional findings and for rigorous preprocessing. The regional distribution of reproducibility measures was different for SDw, CV and ICC. Each one of these measures reveals complementary information that needs to be taken into consideration when performing statistical operations on groups of DT images. Published by Elsevier Ireland Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available