Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 170, Issue 2, Pages 333-336Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2006.02.014
Keywords
memory reconsolidation; instrumental learning; sucrose
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Well-consolidated fear-related memories, once retrieved, are susceptible to disruption and require reconsolidation in order to be maintained. We examined whether reactivated reward-related memories are also susceptible to interference by evaluating the effect of propranolol (PROP), a beta-adrenergic antagonist known to impair reconsolidation of fear-related memories, on context-induced sucrose seeking. PROP administration upon reactivation reduced sucrose seeking behaviour 3 weeks post-training, indicating that reconsolidation of reward-related memories can be disrupted after a long post-training interval. (c) 2006 Elsevier B.V. All rights reserved.
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