Journal
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
Volume 126, Issue -, Pages 139-145Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autneu.2006.02.021
Keywords
hypothalamus; baroreflex; blood pressure; respiration; sympathetic nervous system
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Stressor induces not only cognitive, emotional and behavioral changes but also autonomic changes. Although research on the neural circuits underlying such autonomic changes has implicated the hypothalamus in the defense response against stressors, neurotransmitters in this multifaceted and coordinated response have not been revealed. In this brief review, here we summarize our recent discovery using orexin knockout mice and orexin neuron-ablated mice of possible contribution of orexin in the defense response and discuss future directions. (c) 2006 Elsevier B.V. All rights reserved.
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