Journal
PLOS CLINICAL TRIALS
Volume 1, Issue 2, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pctr.0010012
Keywords
-
Funding
- Medical Research Council [G0000477] Funding Source: researchfish
- Medical Research Council [G0000477] Funding Source: Medline
- MRC [G0000477] Funding Source: UKRI
Ask authors/readers for more resources
Objectives: To study if genes with common single nucleotide polymorphisms ( SNPs) associated with obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic low-fat or high-fat diet. Design: Randomised, parallel, two-arm, open-label multi-centre trial. Setting: Eight clinical centres in seven European countries. Participants: 771 obese adult individuals. Interventions: 10-wk dietary intervention to hypo-energetic ( - 600 kcal/d) diets with a targeted fat energy of 20%-25% or 40%- 45%, completed in 648 participants. Outcome Measures: WL during the 10 wk in relation to genotypes of 42 SNPs in 26 candidate genes, probably associated with hypothalamic regulation of appetite, efficiency of energy expenditure, regulation of adipocyte differentiation and function, lipid and glucose metabolism, or production of adipocytokines, determined in 642 participants. Results: Compared with the noncarriers of each of the SNPs, and after adjusting for gender, age, baseline weight and centre, heterozygotes showed WL differences that ranged from - 0.6 to 0.8 kg, and homozygotes, from - 0.7 to 3.1 kg. Genotype-dependent additional WL on low-fat diet ranged from 1.9 to - 1.6 kg in heterozygotes, and from 3.8 kg to - 2.1 kg in homozygotes relative to the noncarriers. Considering the multiple testing conducted, none of the associations was statistically significant. Conclusions: Polymorphisms in a panel of obesity-related candidate genes play a minor role, if any, in modulating weight changes induced by a moderate hypo-energetic low-fat or high-fat diet.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available