Journal
SMALL
Volume 2, Issue 7, Pages 840-846Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200600083
Keywords
biomedicine; cells; drug development; high-throughput screening; ion channels
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The patch-clamp technique is the state-of-the-art technology for the study of a large class of membrane proteins called ion channels. Ion channels mediate electrical current flow, have crucial roles in cellular physiology, and are important drug targets. However, patch clamping is a laborious process requiring a skilled experimenter and is, therefore, not compatible with the high throughput needed in drug development. The solution for automated and parallel patch-clamp measurements that is provided by microchip technology is presented here.
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