Journal
BLOOD
Volume 108, Issue 1, Pages 305-310Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2006-01-0143
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Funding
- NCI NIH HHS [P01CA 109901, P01 CA109901] Funding Source: Medline
- NIAID NIH HHS [R01AI 45846] Funding Source: Medline
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Overexpression of intracellular Notch plays an important role in the generation of human acute lymphoblastic T cell leukemia (T-ALL). In mouse models, it was shown that Notch-dependent T-ALL required pre-TCR signaling. Here we show that pre-TCR signaling is required to condition mice for Notch-dependent transformation but that it is not required to sustain malignant growth of T-ALL. In contrast to previous studies, we found that disease development does not require pre-TCR but that it can be accelerated in Rag2(-/-) mice by transient mimicking of pre-TCR signals.
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