Journal
CHEMMEDCHEM
Volume 1, Issue 7, Pages 698-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.200600053
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Funding
- NCI NIH HHS [R01 CA99385, P50-CA86355] Funding Source: Medline
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Photodynamic therapy with a molecular switch: Both singlet oxygen generation and near-infrared fluorescence from a photosensitizer were markedly decreased by conjugating multiple chlorine, photosensitizers onto a polypeptide backbone. Protease-mediated cleavage of the backbone results in the formation of degraded probes, which are highly phototoxic and fluorescent.
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